This study aims to investigate the alterations in cervical remodeling and the underlying molecular mechanisms in a lipopolysaccharide (LPS)-induced rat model of preterm birth through RNA sequencing. The results demonstrate that LPS triggers preterm birth by activating inflammatory and bradykinin pathways, disrupting extracellular matrix stability, and promoting cervical insufficiency. At time of import, last updated (by provider) on: Sep 08 2025 Contributors: ; [Yun Liu, Ling Wang, Ming Liu, Lulu Meng, Yijie Gao, Xiaotian NI, Ping Ru]