5-[6-[(4-methyl-1-piperazinyl)methyl]-1-benzimidazolyl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide delivered at dose 0.01 uM (subset of GSE96760 - H-STS NET cell line perturbed with small molecule compounds, see all subsets)

Annotations:	SUBSET, bulk RNA-seq assay, GSK461364
Description:	Expression profile of H-STS NET cell line at 6h and 24h after perturbation with small molecule compounds. At time of import, last updated (by provider) on: May 15 2019 Contributors: ; [Mariano J Alvarez] (inherited)
Accession:	GSE96760  (inherited)
Publication:	Alvarez, Mariano J et al. (2018)   (inherited)
Dimension:	42387 (4/573 samples)
Other subsets:	(2,3-dichlorophenyl)-[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1-indolyl]methanone delivered at dose 5.4 uM 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea delivered at dose 0.25 uM 1-[6-(2-hydroxypropan-2-yl)-2-pyridinyl]-6-[4-(4-methyl-1-piperazinyl)anilino]-2-prop-2-enyl-3-pyrazolo[3,4-d]pyrimidinone delivered at dose 0.08 uM 1h-indole-5-sulfonamide, n-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1h-pyrrol-2-yl]methylene]-2,3-dihydro-n-methyl-2-oxo-, (3z)- delivered at dose 1.52 uM 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol delivered at dose 0.009 uM 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-9-pyrido[1,2-a]pyrimidinyl]ethyl]amino]benzoic acid delivered at dose 0.322 uM 3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-3-piperidinyl]-2-thiophenecarboxamide delivered at dose 0.03 uM 4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one delivered at dose 0.065 uM 4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one delivered at dose 0.65 uM 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid delivered at dose 0.044 uM 4-[hydroxy-[4-[[4-[[(1-naphthalenylamino)-oxomethoxy]methyl]phenyl]methylamino]butyl]amino]-4-oxo-2-butenoic acid methyl ester delivered at dose 0.072 uM 4-[hydroxy-[4-[[4-[[(1-naphthalenylamino)-oxomethoxy]methyl]phenyl]methylamino]butyl]amino]-4-oxo-2-butenoic acid methyl ester delivered at dose 0.72 uM 5-[6-[(4-methyl-1-piperazinyl)methyl]-1-benzimidazolyl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide delivered at dose 0.05 uM 5Z-7-oxozeaenol delivered at dose 0.22 uM 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-3,4-dihydro-1H-quinolin-2-one delivered at dose 2.08 uM 7-(3,5-dimethyl-4-isoxazolyl)-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-3H-imidazo[4,5-c]quinolin-2-one delivered at dose 0.88 uM 7-(3,5-dimethyl-4-isoxazolyl)-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-3H-imidazo[4,5-c]quinolin-2-one delivered at dose 1.32 uM AZD-8055 delivered at dose 2 uM AZD-8055 delivered at dose 20 uM BGJ-398 delivered at dose 4.56 uM BI2536 delivered at dose 0.009 uM BIO delivered at dose 3 uM BKM120 delivered at dose 1.2 uM BMS-754807 delivered at dose 0.72 uM Bafetinib delivered at dose 3.24 uM Bardoxolone methyl delivered at dose 0.15 uM CD437 delivered at dose 0.236 uM CHM-1 delivered at dose 0.084 uM DBeQ delivered at dose 1.6 uM FK866 delivered at dose 20 uM Gossypol delivered at dose 4.44 uM INC280 delivered at dose 20 uM JNJ-26854165 delivered at dose 0.6 uM KHS101 delivered at dose 1.2 uM KX2-391 delivered at dose 0.024 uM Ku-0063794 delivered at dose 0.04 uM LSM-1131 delivered at dose 0.0709 uM LSM-1131 delivered at dose 0.709 uM MK-2206 delivered at dose 0.684 uM MK-2206 delivered at dose 6.84 uM ML-210 delivered at dose 0.04 uM N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamide delivered at dose 0.64 uM N-(2-phenylphenyl)-8-[4-(3-pyridinyl)-1-triazolyl]octanamide delivered at dose 7.4 uM N-(4-methoxyphenyl)sulfonyl-N-[2-[2-(1-oxido-4-pyridin-1-iumyl)ethenyl]phenyl]acetamide delivered at dose 0.1 uM N-(6-butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester delivered at dose 0.054 uM N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methyl-4-thieno[3,2-d]pyrimidinyl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide delivered at dose 0.008 uM N-[3-[[(2,3-dihydroxyphenyl)-oxomethyl]amino]phenyl]-2,3-dihydroxybenzamide delivered at dose 1.68 uM N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide delivered at dose 4 uM N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal delivered at dose 0.25 uM N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide delivered at dose 0.214 uM N3-cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine delivered at dose 0.06 uM NVP-231 delivered at dose 0.028 uM NVP-231 delivered at dose 0.27 uM Nutlin-3 delivered at dose 0.84 uM Obatoclax delivered at dose 0.068 uM Obatoclax delivered at dose 0.68 uM PAC-1 delivered at dose 4 uM PHA-665752 delivered at dose 2.88 uM Piplartine delivered at dose 1.04 uM Ribociclib delivered at dose 26.32 uM SB-743921 delivered at dose 0.0004 uM SCH-529074 delivered at dose 0.48 uM SNX-2112 delivered at dose 0.006 uM SNX-2112 delivered at dose 0.066 uM Y-27632 delivered at dose 3.36 uM YM-155 delivered at dose 0.00006 uM YM-155 delivered at dose 0.0007 uM [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone delivered at dose 5.52 uM afatinib delivered at dose 1 uM alpelisib delivered at dose 19.4 uM alvocidib delivered at dose 0.048 uM arachidonyl group delivered at dose 7.44 uM belinostat delivered at dose 0.00325 uM belinostat delivered at dose 0.0325 uM bexarotene delivered at dose 20 uM bortezomib delivered at dose 0.0088 uM bortezomib delivered at dose 0.02 uM brefeldin A delivered at dose 0.042 uM brivanib delivered at dose 7 uM ceritinib delivered at dose 2.8 uM cerulenin delivered at dose 0.68 uM ciclopirox delivered at dose 5 uM crizotinib delivered at dose 0.48 uM dasatinib (anhydrous) delivered at dose 0.004 uM docetaxel trihydrate delivered at dose 0.002 uM doxorubicin delivered at dose 0.008 uM entinostat delivered at dose 0.684 uM entinostat delivered at dose 6.84 uM epigallocatechin gallate delivered at dose 15.12 uM erastin delivered at dose 10 uM erastin delivered at dose 15 uM everolimus delivered at dose 5.88 uM fingolimod delivered at dose 4 uM fluvastatin delivered at dose 0.76 uM gemcitabine delivered at dose 0.05 uM gemcitabine delivered at dose 0.15 uM ibrutinib delivered at dose 2.4 uM imatinib delivered at dose 2 uM imatinib delivered at dose 20 uM istradefylline delivered at dose 20 uM leptomycin B delivered at dose 0.00012 uM linifanib delivered at dose 5 uM luminespib delivered at dose 0.02 uM manumycin A delivered at dose 4.32 uM midostaurin delivered at dose 2.84 uM mithramycin delivered at dose 0.024 uM mitomycin C delivered at dose 0.44 uM necrosulfonamide delivered at dose 4 uM neratinib delivered at dose 0.25 uM nilotinib delivered at dose 7.68 uM onalespib delivered at dose 0.07 uM paclitaxel delivered at dose 0.003 uM panobinostat delivered at dose 0.005 uM parthenolide delivered at dose 0.8 uM pictrelisib delivered at dose 0.05 uM pluripotin delivered at dose 0.005 uM reference substance role rigosertib delivered at dose 0.1 uM rosiglitazone delivered at dose 20 uM sorafenib delivered at dose 3.72 sunitinib delivered at dose 0.176 uM sunitinib delivered at dose 1.76 uM topotecan delivered at dose 0.00138 uM topotecan delivered at dose 0.0138 uM vincristine delivered at dose 0.0008 uM vorinostat delivered at dose 0.2 uM
Assays:	A1BG A2M A2MP1 NAT1 NAT2 SERPINA3 AADAC AAMP AANAT AARS1 ABAT ABCA1 ABCA2 ABCA3 ABCB7 ABCF1 ABCA4 ABL1 AOC1 ABL2 GSK461364_0.01_6 [CR10A9] GSK461364_0.01_24 [CR10C9] GSK461364_0.01_24 [CR10C10] GSK461364_0.01_6 [CR10A10]
Annotations:	Category Value study design SUBSET (inherited) assay bulk RNA-seq assay (inherited)